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12 Because its oxidative functions require GSH to be in its reduced form, GSSG is reduced to regenerate GSH in a reaction catalyzed by GSH reductase that requires reduced nicotinamide adenine dinucleotide phosphate (NADPH) as a hydrogen donor (Figure 2)

Hyperbaric oxygen has also been shown to regenerate blood vessels and nerve fibers, reduce swelling and inflammation in the brain, and increase stem cell circulation

doi: 10.3389/fcell.2025.1559300 Received 12 January 2025 Accepted 29 May 2025 Published 09 June 2025 Volume 13 - 2025 Edited by Ariane Zamoner, Federal University of Santa Catarina, Brazil Reviewed by Belm Sampaio-Marques, University of Minho, Portugal Heidar Heidari Khoei, Austrian Academy of Sciences (OeAW), Austria Updates Copyright 2025 Khodaei, Noori, Zare and Meshkin

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