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According to the SmPC, the medication has a half-life of approximately one week, resulting in continuous effects on gastric emptying and gut motility throughout the dosing period, meaning gastrointestinal symptoms may occur at any time, though they are often most pronounced in the days following dose escalation

Smith MA, Makino S, Kvetnansky R, Post RM

According to a presentation at the Annual Scientific Meeting of the Society of Interventional Radiology in Los Angeles, freezing part of the vagus nerve seemed to result in decreased appetite and weight loss in 10 patients