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The company's rationale for oral delivery is based on BPC-157's natural presence in gastric juice, which suggests inherent gastric stability

Coordination of the cognate metal thus drives transcriptional derepression (an ON switch mediated by allosteric inhibition of DNA operator binding by metal) (Figure 6A, top ), transcriptional corepression (an OFF switch mediated by allosteric activation of DNA binding) of downstream genes (Figure 6A, middle ), or transcriptional activation (an ON switch mediated by metal-dependent conformational changes in the bound DNA, converting a weak promotor to a strong promoter) (Figure 6A, bottom )