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(2012) confirmed that YGJ can also inhibit the transfer of bone marrow cells to the liver, further inhibit the differentiation of bone marrow cells, inhibit the proliferation of hepatocytes and progenitor cells in the injured liver, and ultimately play a role in the treatment of liver fibrosis and fundamentally prevent the formation of cirrhosis

The efflux mechanism is counteracted by thiopurine cellular circulation , whereby thiopurine nucleotides extruded by ABCC4 will be salvaged by an extracellular enzyme NT5E through hydrolysis into nucleosides, before being transported back into the cells by nucleoside transporters (Li et al., 2010)