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PRKCSH encodes for a protein called hepatocystin or 80K-H, which is a beta subunit of glucosidase II 26 and substrate for protein kinase C 26 , that plays a key role in GLUT4 vesicle trafficking (translocation of GLUT4 to the plasma membrane) in the insulin signaling pathway 72 by forming a complex with 80K-H Overexpression of the hepatocystin 1 week after 4-week intermittent fasting is suggestive of improvement of insulin signaling through enhancement of GLUT4 vesicle trafficking

It participates in the tricarboxylic acid cycle and glucose metabolism within the body, and can activate various enzymes, such as sulfhydryl group (SH) enzymes and coenzymes, thereby promoting the metabolism of carbohydrates, fats, and proteins

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Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles