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The biggest obstacle to the discovery of therapeutics for sepsis is its diverse etiology among patients (55), which have prompted researchers to study the molecular mechanism of sepsis progression based on systemic inflammatory responses

Analytical methods such as principal component analysis (PCA) and machine learning (supervised and unsupervised) stratify tumors into aggressive and non-aggressive and decipher novel biological insights (277)

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According to this model, myosin motors, actin cytoskeleton, and cell adhesion molecules like integrins (clutches) cooperate and coordinate to facilitate cell migration [91,92,93]