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Starting at a higher dose dramatically increases the risk and severity of gastrointestinal side effects

Sulforaphane (0.1 M) was shown in this model to be protective against CysDA-induced neuronal injury, correlating with increased NRF2 pathway activation, enhanced NQO1 activity and restored GSH levels (Vauzour et al., 2010)

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Using the data, the researchers simulated seven clinical trials, testing what effect GLP-1s appeared to have on people with existing substance use disorders, as well as whether they appeared to prevent substance use disorders from developing