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Symptoms of alcohol poisoning include confusion, difficulty staying conscious, vomiting, seizures, slow or irregular breathing, and bluish, pale, or cold skin

Nature 2016;530, 184-189, doi:10.1038/nature16932

Similarly, IL-6 drives renal fibrosis by activating STAT3 in fibroblasts and upregulating vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells (144)