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Methods Number of Prescriptions and Gross Spending Data: This analysis uses 2019 through 2024 State Drug Utilization Data (SDUD) (downloaded in January 2026)

Sixty to eighty-five percent of patients improve with exposure-response prevention treatment, although for up to 30% of patients this treatment is not effective, or patients refuse or discontinue treatment due to the anxiety associated with the exposure (Grant 2014

A potential role for dysfunctional astrocytic Put-GABA tonic inhibition has also been proposed in models of both depression and post-traumatic stress (Michels et al., 2014