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Phase 2 data in type 2 diabetes showed CagriSema reduced HbA1c by 2.2 percentage points compared to 1.8 with semaglutide alone and 0.9 with cagrilintide alone, while achieving 15.6% weight loss versus 5.1% with semaglutide alone

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Using in vitro cell-based assays, the researchers found that while both peptides activated the amylin and calcitonin receptors, KBP-336 was more potent and showed a bias towards the calcitonin receptor compared to cagrilintide