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Abbreviations Akt: Protein kinase B CDKs: Cyclin-dependent kinases ERK: Extracellular-signal-regulated kinases IB: Inhibitor of NF-B IKK: IB kinase IGF: Insulin-like growth factor IL-1: Interleukin-1 IL-2: Interleukin-2 IL-6: Interleukin-6 JNK: C-Jun N-terminal kinases LPS: Lipopolysaccharides MAPK: Mitogen-activated protein kinase MREs: Metal-response elements MT: Metallothionein MTF-1: Metal-regulatory transcription factor 1 NF-B: Nuclear factor kappa B NK cells: Natural killer cells PI3K: Phosphatidylinositol 3-Kinase ROS: Reactive oxygen species SOD: Superoxide dismutase Sp1: Specificity protein 1 TNF-: Tumor necrosis factor-alpha TRAF2: TNF receptor-associated factor 2 ZnT1: Zinc transporter 1 ZnT2: Zinc transporter 2 ZnT3: Zinc transporter 3 ZnT4: Zinc transporter 4 References Sun XR, Xu S, Liu TJ, Wu JW, Yang J, Gao XJ

Both trials demonstrated twice daily oral doses of nerandomilast (9 mg and 18 mg) significantly reduced the decline in forced vital capacity (FVC) from baseline at week 52, compared to placebo (adjusted mean change from baseline in FVC: FIBRONEER-IPF, -138.6 mL with nerandomilast 9 mg, -114.7 mL with nerandomilast 18 mg, -183.5 mL with placebo

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