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These factors govern hemoglobin production, membrane protein assembly, and the enucleation process, enabling the transition of red blood cells from nucleated precursors to mature, enucleated cells specialized for efficient oxygen transport (19) (Figure 2)

This was explored further in Round 2 where a robust consensus was reached on SGLT2is being the preferred first-line therapy for mild and moderate CKD for adults with BMI 100 clinical experts to address gaps in existing evidence and guidelines regarding the optimal treatment positioning and sequencing of SGLT2is and GLP-1 RAs in adults with CKD and T2D with or without overweight/obesity

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