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Cyclosporine is generally reserved for short-term use or as a bridge therapy, particularly in patients without pre-existing renal or cardiovascular conditions, to ensure its benefits outweigh the risks

Russo A, DeGraff W, Friedman N, Mitchell JB: Selective modulation of glutathione levels in human normal versus tumor cells and subsequent differential response to chemotherapy drugs

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An entirely separate candidate gene study involving 275 patients who had suffered acute liver failure after either deliberate or accidental APAP overdose also reported some borderline significant associations.68 For the rs1467558 CD44 variant discussed above, there was a trend towards significance in those who had overdosed unintentionally