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doi: 10.1111/j.1461-0248.2008.01258.x 36 YinHXuLPorterNA

After treatment with metformin alone, lactate levels increased abnormally in HEB, U87, and T98G cells, possibly related to the side effects of metformin

This phenomenon, which is known as the 'somatopause', has led to recombinant human GH being widely promoted and abused as an antiageing drug, despite lack of evidence of efficacy