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Tachyphylaxis, a progressive decrease in the gastric emptying effect over time, has been demonstrated with long-term use of weekly formulations such as semaglutide and tirzepatide [4, 22]
Cryptotanshinone can inhibit oxidative stress, inflammation and ferroptosis by activating MAPK/ERK signaling to prevent ovarian tissue damage in PCOS (108)
If weight loss occurred rapidly without enough time for metabolic adaptation, the body may attempt to regain weight as a protective response
GLP-1R signaling enhances glucose-dependent insulin secretion by activating of G s , upregulating of cAMP, and subsequently activating of PKA (110)
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