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It reduces the activity of tyrosinase by three different mechanisms: (i) chelation of the copper site by its thiol group, (ii) interfering with the cellular transfer of tyrosinase to premelanosomes which is a prerequisite for melanin synthesis, and (iii) indirectly via its antioxidant effect.[] Glutathione shifts melanogenesis from eumelanin to phaeomelanin synthesis by reactions between thiol groups and dopa-quinone leading to the formation of sulfhydryl-dopa conjugates.[] It has also been found to be scavenger of UV radiation-induced reactive oxygen species generated in epidermal cells.[] METHODS This was a prospective comparative study to assess and compare the therapeutic efficacy of localized TA and glutathione for treatment of facial melasma over a period of 18 months (December 2017 to May 2019) conducted in department of dermatology on OPD basis in a tertiary care center

sapiens GRCh38 reference genome was used for mapping RNA-seq reads