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In hidradenitis suppurativa (HS), there appears to be a dysregulated adipokine release that is shifted towards pro-inflammatory adipokines

Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells

Dose adjustments, splitting your dose across the week , or temporarily reducing your dose can often resolve issues without discontinuing treatment entirely