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Erythrocyte studies have previously reported eryptosis inducing concentrations for oridonin, cordycepin and apigenin on nave erythrocytes at 25 M, 31 M, and 15 M, respectively ( Among the six eryptosis inducer compounds tested in our study, only apigenin and amiodarone have been previously tested on malaria parasites ( P

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On the other hand, PERK induces translation initiation factor eIF2 phosphorylation (Han et al., 2013), which activates (ATF4) and CHOP and eventually culminates in apoptotic cell death