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It is well established that iron overload and more generally ferroptosis can trigger macrophage polarization, increasing M1-like markers such as IL-6, IL-1, and TNF, while decreasing M2-like markers [25, 26]

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No difference between smokers and nonsmokers regarding supplemental and dietary intakes of antioxidant micronutrients, including selenium, was found to contribute to the association of smoking and rectal cancer (68)

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Lower doses provide sustained pathway support without aggressive intervention

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