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The UPR signaling pathway is mainly mediated by protein kinase RNA-like ER kinase (PERK), inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6)

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When tested for episodic memory, subjects given a placebo prior to their THC administration showed a significant impairment while those given CBD performed on par with the control group given no THC, thus highlighting CBDs ability to prevent drug-induced memory dysfunction