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Int J Mol Sci (2021) 22(8):3923

Working with rodent models, research demonstrates that GLP-1 drugs affect reward processing in the brain, and ongoing efforts are working to reduce the gastrointestinal side effects of these drugs

The absence of RCTs among the included studies is a notable limitation, as observational and retrospective designs may be more susceptible to confounding, selection bias, and variability in data quality

Mainly owing to its close association with the components of the metabolic syndrome, i.e., type 2 diabetes mellitus (T2DM), obesity, arterial hypertension and dyslipidemia, a change in the nomenclature of the disease to metabolic dysfunction-associated steatotic liver disease (MASLD) together with a change to the definition of the disease have been proposed [2]