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Bowel Obstruction and Other GLP-1 GI Risks The FDA had received more than 1,200 reports of ileus and bowel obstructions from people taking Ozempic as of June 2026

9 However, according to the 2018 Clinical Practice Guidelines from Diabetes Canada, it is recommended that DPP-4 inhibitors, GLP-1 receptor agonists, or SGLT2 inhibitors be considered first as hypoglycemia and weight gain are less of an issue with these agents, provided contraindications, accessibility, and affordability are considered

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