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Pretreatment screening is advisable to check for the possible presence of liver disease in patients being considered for methotrexate treatment

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Direct SlC7A11 overexpression in cardiac myocytes boosted GSH levels and reduced cardiac ferroptosis and injury, suggesting that it is feasible to fortify GSH levels by increasing SLC7A11 [76]

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The lack of data had previously led societies to rely on expert opinion for guidance

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