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In the published Phase 2 research (Jastreboff et al., NEJM 2023), Retatrutide produced the largest body-weight outcomes of any single-compound incretin programme reported to date, distinguishing the triple-agonist class from dual agonists like Tirzepatide and single-target agonists like Semaglutide

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Widely referenced in preclinical literature for its interaction with VEGF, FAK-paxillin, and nitric oxide pathways