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Because the data in the TriNetX platform is HIPAA de-identified, and therefore, by definition is deemed to allow no access to protected health information (and therefore no risk of protected health information disclosure), Institutional Review Boards (IRBs) have no jurisdiction of studies using HIPAA de-identified data 53

Rybelsus Rybelsus is the first FDA-approved oral GLP-1 agonist

Medications and Supplements In some cases, anti-nausea medications like ondansetron or meclizine may be necessary to alleviate persistent nausea

In November and December 2025, the two largest clinical trials ever run with a glucagon-like peptide-1 receptor (GLP-1R) agonist in a neurodegenerative disease reported their results