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TREM2 variants in Alzheimers disease
3.2.1 TGVS theory According to the TGVS theory, which combines blood vessels, nerves, and neurotransmitters, the trigeminal nerve and peri-vascular nerve fibers both inside and outside the skull serve as the main pathways for transmitting pain in migraines
Even though there are concerns for the development of kidney disease in CPTII patients due to the high metabolic overload associated to rhabdomyolysis, end-stage chronic renal insufficiency requiring dialysis is only occasionally reported in these patients ( A Difficult Muscle Disease to Diagnose CPTII muscle deficiency is not easily recognized and patients may have to wait for decades just to get a proper diagnosis, generally based on referred symptoms (Sigauke et al., 2003)
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