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Purified water, cyclohexasiloxane, zinc oxide, propanediol, lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone, butyloctyl salicylate, butylene glycol dicaprylate/dicaprate, niacinamide, coco-caprylate/caprate, 1,2-hexanediol, disteardimonium hectorite, neopentyl glycol diheptanoate, sodium chloride, *sodium hyaluronate, ceramide NP, *hyaluronic acid, *hydrolyzed sodium hyaluronate, *hydrolyzed hyaluronic acid, *sodium acetylated hyaluronate, *hydroxypropyl trimonium hyaluronate, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, Sorbitan Sesquioleate, Triethoxyca Prylylsilane, VP/ACOSIN Copolymer, Polyglyceryl-4 Oleate, Polyhydroxystearic Acid, Hydrogenated Rapeseed Oil, Hydrogenated Palm Oil, Tocopherol, Polyglyceryl-3 Polyricinoleate, Adenosine, Butylene Glycol, Caprylic/Capric Triglyceride, Phosphatidylcholine, *Sodium Hyaluronate Crosspolymer, Glycine, Serine, Glutamic Acid, Lysine,Alanine, threonine, proline, arginine
P.KovacsR.HuchzermeyerC.KannO.et al (2010)
Thus, they are likely gain-of-function variants in which a background cation leak leads to cellular hyperexcitability, as generally is reported in other dominantly-inherited channelopathies (85)
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