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A version called tirzepatide, made by Eli Lilly, has also significantly reduced body weight in trials
Anti-icodec and anti-semaglutide antibodies were measured by validated assays
However, individuals with a medical or family history of thyroid cancer or those with multiple endocrine neoplasia syndrome type 2 (MEN2) should exercise caution, as GLP-1 is not recommended for this demographic
Verdict at a Glance Orforglipron represents a potential paradigm shift as the first oral non-peptide GLP-1 agonist without fasting restrictions, and it demonstrated superiority over oral semaglutide in the head-to-head ACHIEVE-3 trial for both HbA1c and weight loss
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