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Side Effects: What You Need to Know Hydroquinone Side Effects Hydroquinone misuse or prolonged use can lead to: Chronic irritation Uneven whitening or patchiness Thinning of the skin Rebound darkness after stopping Exogenous ochronosis (rare but serious bluish-black discoloration) These risks increase when hydroquinone is: Used without medical supervision Applied longer than recommended Combined with sun exposure Mixed with steroid creams Alpha Arbutin Side Effects Alpha arbutin is considered one of the safest brightening agents available

Each time a cell divides, telomeres shorten, eventually triggering cellular senescence or apoptosis - effectively limiting the replicative lifespan of normal somatic cells to approximately 50-70 divisions (the Hayflick limit)

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Changes in SOD activity in plasma confirmed former reports that the antioxidant system is impaired in active CD (12)