Metformin typically achieves A1C reductions of 1.0-1.5% as monotherapy, depending on the baseline level
With 17 DMTs available for the treatment of MS (Figure 1), clinicians are faced with the critical decision of how to screen MS patients for potential risk of malignancy with currently available DMTs and how to manage DMTs in MS patients who either had prior history of cancer or newly develop cancer while on a DMT

oz.) Water/Aqua/Eau, C12-15 Alkyl Benzoate, Caprylic/Capric Triglyceride, Dicaprylyl Carbonate, Propanediol, Shea Butter Ethyl Esters, Glycerin, Cetearyl Alcohol, Behenyl Alcohol, Bentonite, Glyceryl Stearate, Hydrogenated Vegetable Glycerides, PEG-100 Stearate, Dimethicone, Isoamyl Laurate, Hydrogenated Vegetable Oil, Hydrogenated Soybean Oil, Butylene Glycol, Sodium Hyaluronate, Copper Tripeptide-1, Phosphatidylcholine, Acetyl Hexapeptide-8, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Dimethyl MEA, Tetrahexyldecyl Ascorbate, Tyrosine, Hydro- lyzed Myrtus Communis Leaf Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Polysorbate-20, Dimethyl Isosorbide, Polysilicone-11, Phenoxyethanol, Petrolatum, Hydrogenated Olive Oil, Caprylyl Glycol, Coco-Glucoside, Hydrogenated Jojoba Oil, Echium Plantagineum Seed Oil, Citric Acid, Glycolic Acid, Helianthus Annuus (Sunflower) Seed Oil, Glycine Soja (Soybean) Lipids, Carbomer, Disodium EDTA, Phytosterols, Ethylhexylglycerin

The procedure is performed laparoscopically through small incisions