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Always check for signs that semaglutide may no longer be effective including changes in its appearance, such as discoloration or cloudiness

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The FDA and medical community emphasize caution with compounded GLP-1s Healthline+2Houston Chronicle+2 Notably, the FDA has ended certain emergency provisions allowing compounded semaglutide production, signaling that compounding may be restricted unless specific clinical justification is documented Empower Pharmacy+2Houston Chronicle+2 Pros, Risks & Monitoring At Cleveland Care Clinic, we would approach this option only under strict oversight: starting with lower doses, frequent follow-ups, lab monitoring (e.g