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The broad substrate specificity of GSTs allows them to protect cells against a range of toxic chemicals, and a lack of these enzymes is a disadvantage for the susceptible individual (Salinas and Wong 1999) whose risk may increase in many biochemical pathways

Further assessment of mitochondrial membrane potential employing the selective fluorescent probe MitoTracker Red CMXRos, showed depolarized mitochondria in resting CD38-expressing as compared to CD38 T cells (Supplementary Fig

These side effects are generally transient and may decrease over time as the body adjusts to the medication

2.6 Real-time PCR analysis Total RNA was prepared from liver tissues and LO2 cells using the simple RNA Extract kit (Tiangen Biotech, China) and reverse transcription of RNA to cDNA using Fast King cDNA First Strand Synthesis Kit (Tiangen Biotech, China)