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The research rationale established by NNMT-knockdown studies in diet-induced-obese mice is that inhibiting NNMT preserves intracellular NAD+ and SAM levels, which in adipocyte (fat-cell) models has been shown to suppress de novo lipogenesis

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By targeting the NNMT pathway, it helps restore metabolic balance , enhance energy , and potentially support sustainable fat loss without stimulants or hormonal interference