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Furthermore, elevated cytosolic aconitase (c-ACNT) and isocitrate dehydrogenase (ICD2), synergistically enhanced by iron accumulation, drive citrate flux toward NADPH and -KG generation, thereby exacerbating intracellular citrate depletion

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In trials, Zepbound showed slightly greater average weight loss at the highest doses (about 20% vs about 15%)