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These results are in line with previous findings indicating that inhibition of mitochondrial complex I synergizes with mitochondrial antioxidants in impairing cancer cell fitness, supporting the notion that complex I is a dominant determinant of viability ( Figure 2 2.3 DPI synergizes with vincristine and MitoQ in reducing cell viability of MNA NB cells Finding synergistic drug combinations allows for combining drugs at lower concentrations, which is an important strategy for enhancing therapeutic efficacy while minimizing adverse effects

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[49] [50] [51] For post-operative oral supplementation, 1000 g/d may be needed to prevent vitamin deficiency

There is not as much evidence regarding long-term efficacy or safety of gel vitamin B12 compared to injections, but at this time it appears B12 gel works similarly to raise blood levels