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For infection experiments, female knockout or transgenic mice and their age-matched wild-type (WT) littermate controls were used

doi: 10.1016/j.intimp.2020.107087, 111

The Safety Summary The Bottom Line For treating specific hyperpigmentation dark spots, PIH, melasma, uneven patches topical kojic acid has significantly stronger clinical evidence, a well-established safety profile, and a targeted mechanism that addresses the actual biology of those spots

In addition, flavonoids can also regulate mast cells, eosinophils, and other immune cells, thereby alleviating allergic reactions and autoimmune diseases (128, 129)