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erythematotelangiectic, papulopustular, phymatous, and ocular rosacea.1 The most common manifestation is erythematolangiectatic rosacea, which presents in approximately 57% of patients with rosacea, and papulopustular rosacea, which presents in approximately 43% of patients with rosacea

The downstream effects most consistently described in the literature: induction of collagen I and III, elastin, and decorin synthesis (Maquart et al., FEBS Letters , 1988), upregulation of VEGF and basic FGF transcripts, induction of antioxidant defense genes including SOD2 and metallothionein isoforms, and modulation of the MMP-2 and TIMP-1/2 balance toward non-fibrotic remodeling

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(2013) confirmed that genistein treatment of HepG2 cells could increase both hepcidin promoter activity and transcript levels