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W., Wade, K

induction of linear growth patterns, gain of body weight, induction of liver enzymes and STAT 5b signaling pathway activity (465)

Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies

Neither the Summary of Product Characteristics (SmPC) for Rybelsus nor major drug interaction databases identify ibuprofen as a contraindicated or significantly interacting medication