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The GLP-1 group showed markedly lower risks of severe complications, including sepsis, acute kidney injury, shock, and the need for mechanical ventilation

Yet emerging evidence reveals that GIP agonism produces appetite suppression and weight loss comparable to or exceeding GLP-1 agonismand when combined, GIP and GLP-1 agonism produces synergistic metabolic effects of remarkable magnitude

This functional improvement was accompanied by restoration of the oxidant/antioxidant balance, as evidenced by reduced MDA and increased SOD activity

In brief, atorvastatin can significantly regulate the serum LDL-C level in model animals by regulating the PPAR signaling pathway and HMGCR gene expression