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mRNA therapeutics, illustrated by the Moderna and BioNTech COVID-19 vaccines, involve at least four distinct IP layers: the lipid nanoparticle delivery system, the mRNA sequence design (UTR elements, cap analogues, modified nucleotides), the encoded antigen or protein sequence, and manufacturing processes

408 The acidic extracellular microenvironment has become an effective disease diagnosis and treatment target

For managing symptoms of severe itching in patients with cholestatic DILI, antihistamines like hydroxyzine or diphenhydramine, or bile acid resins like cholestyramine, can be helpful

Anyone weighing a GLP-1 medication should treat the initial visit as a conversation, not a purchase