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10.3390/cells12030417 Cells 167 KimS.KwonS.-H.KamT.-I.PanickerN.KaruppagounderS

Lillys patent for tirzepatide expires in 2036, and FDA-approved generic versions of Mounjaro and Zepbound could be available in 2039

Understanding these distinctions helps researchers make more informed decisions when evaluating available literature and designing future investigations

The first GIP receptor antagonist was introduced in 1986 ( Figure 3 ), and in recent years, the truncated and deactivated form of GIP, GIP(3-30)NH 2 , has proven to be a potent and specific GIP receptor antagonist in humans in high concentrations, and suitable for studies of endogenous GIP physiology and pathophysiology ( Table 1 )