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We also found that SQSTM1 was significantly up-regulated by riboflavin deficiency in this study

Acta Pharmacol Sin 40(6):814822 Cheng T, Sudderth J, Yang C et al (2011) Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

In brief, its canonical pathway is activated by damage-associated molecular patterns (DAMPs) or pathogen-associated molecular patterns (PAMPs), which stimulate the assembly of the NLRP3 inflammasome, gasdermin D pore formation, and release of IL-1 and IL-18