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The CNS in humans presents considerable anatomical, immunological, and functional challenges, and ensuring that regenerated neurons integrate meaningfully into pre-existing circuits without causing maladaptive rewiring or excitotoxicity is a task of extraordinary complexity

From the point of view of KP and other inflammatory skin concerns, curcumin displays potent anti-inflammatory properties specifically within soft tissue structures such as skin and intestines

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The bottom line on human data: promising signals, no randomized controlled trials, and no long-term safety data in humans