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It is known for its simplicity and reliability ( The pristane-induced arthritis (PIA) model is primarily utilized to investigate the mechanisms of inflammatory arthritis, particularly those involving T cell activation and the role of autoantibodies in the disease process ( The K/BxN model is designed to investigate the pathogenesis of RA, particularly the role of autoantibodies and T cells in the development of joint inflammation and damage ( All these models developed histopathological changes, such as synovial hyperplasia, infiltration of immune cells (e.g., T cells, B cells, and macrophages), cartilage destruction, and bone erosion (Figure 1)

Polyphenols are found to have modulatory effects on mitogen-activated protein kinases (MAPKs), NF-B, phosphatidylinositol 3-kinase (PI3K/Akt), and Wnt/-catenin networks and prevent the occurrence of inflammatory disorders (Jantan et al., 2021)

Minimize side effects by staying hydrated and resting adequately

Is this a habit forming medicine