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Cisplatin is able to bind directly to the sulfhydryl groups of antioxidant enzymes in the cochlea, leading to the inactivation of the enzymes, and it also decreases the levels of glutathione and NADPH (Nicotinamide Adenine Dinucleotide Phosphate), both of which are essential for the activity of the enzyme glutathione peroxidase ( Reactive oxygen species (ROS) and their derived superoxide radicals can trigger cytotoxic effects through multiple mechanisms: first, excessive generation of ROS induces lipid peroxidation and leads to depletion of intracellular antioxidant enzyme levels, exacerbating the disruption of redox homeostasis

Sies, 2015)

Recent research has uncovered that AARS1 functions as a lactate transferase that detects intracellular lactate levels and translocates to the nucleus to mediate lactylation, thereby activating the YAP-TEAD complex

Neurotherapeutics 7 , 439451 (2010)