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462 Inhibition of the NF-B signaling pathway leads to the decreased production of inflammatory mediators, including adhesion molecules and chemokines, which are crucial for the recruitment of immune cells to sites of inflammation

In this model, genes associated with the one-carbon metabolic pathways, including the folate and methionine cycles, are up-regulated in the fungal cells upon infection, and are supposed to result in enhanced biosynthesis of nucleotides, NADPH, glutathione and methyl groups

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doi: 10.1038/nature11209 21 HettaHFRamadanYNAlharbiAAAlsharefSAlkindyTTAlkhamaliAet al