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However, calorie restriction for a longer duration may also lead to unregulated autophagy, which may subsequently cause an adverse impact on the patient and thereby cause a loss of therapeutic advantage [139]

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Given the essential role of astrocytes in clearing and detoxifying many substances and the changes in astrocyte functions that such substances can evoke, it is interesting to consider (and worthy of more extensive investigation) that chronic exposure to trace amounts of such substances might act as risk factors and comorbidities in a variety of CNS neurodegenerative conditions

See what the study found in the Pain section of our CBD Oil and Hemp Extracts Review