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Bioavailability determines what percentage of the injected dose actually reaches systemic circulation

2001 May;65(5):1104-11

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In addition, it has been shown that neutrophils are altered early in VA-ECMO by elevated plasma levels of granulocyte colony stimulating factor, leading to an increase in the proportion of immature neutrophils, which exert immunosuppressive effects, reducing phagocytic activity and pathogen clearance, and is an important cause of acquired infections in critically ill patients treated with extracorporeal circulatory support (83)