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Clinical trials have evaluated once per day formulations [41], as well as formulations that were applied 3 times per day [42] and up to 6 times per day [43] without evidence of therapeutic effect

In short, compounded medications are not FDA-approved, but they are permitted as long as these guidelines are followed and are subject to oversight to ensure safety and quality

Results maintenance demands ongoing use or periodic intensive cycles - stopping treatment initiates gradual regression over 2-6 months as new collagen formation ceases and natural degradation continues

This is primarily due to magnesiums interaction with the N-methyl-D-aspartate (NMDA) receptor, which blocks the calcium channel and prevents excessive glutamatergic excitatory signaling