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Specific mechanisms under investigation include critical pathways involved in the generation of and protection against oxidative stress

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Non-steroidal topical therapies targeting phosphodiesterase-4 (PDE4) (e.g., crisaborole ointment) or Janus kinase (JAK) (e.g., ruxolitinib cream, a JAK1/2 inhibitor) have shown efficacy in several case reports of CHE